140 Results for "

Simsia foetida (Cav.) S.F.Blake

" in MedChemExpress (MCE) Product Catalog:
Products (140)

140 Results for "Simsia foetida (Cav.) S.F.Blake" in MCE Product Catalog:

81
L-Ascorbic acid
L-Ascorbic acid
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81 Publications Verification
Cat. No.: HY-B0166
CAS No.: 50-81-7
Synonyms: L-Ascorbate; Vitamin C
Category:  

Natural Products Neurological Disease Moringa oleifera Lam. Metabolic Disease Endocrine diseases Plants Endogenous metabolite Disease markers Moringaceae Nervous System Disorder Disease Research Fields

Target:  

Environmental Pollutants Endogenous Metabolite Calcium Channel Reactive Oxygen Species (ROS) Apoptosis

L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
81
L-Ascorbic acid sodium salt
L-Ascorbic acid sodium salt
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81 Publications Verification
Cat. No.: HY-B0166A
CAS No.: 134-03-2
Synonyms: Sodium ascorbate; Sodium L-ascorbate; Vitamin C sodium salt
Category:  

Natural Products other families Plants Disease Research Fields Cancer

Target:  

Environmental Pollutants Apoptosis Endogenous Metabolite Calcium Channel Reactive Oxygen Species (ROS)

L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor .
4
Demethylsuberosin
Demethylsuberosin
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4 Cited Publications
Cat. No.: HY-N2488
CAS No.: 21422-04-8
Synonyms: 7-Demethylsuberosin
Category:  

Monophenols Coumarins Phenols Phenylpropanoids Plants Umbelliferae Disease Research Fields Inflammation/Immunology Echinacea angustifolia DC.

Target:  

Calcium Channel NO Synthase

Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound found in Angelica gigas Nakai. Demethylsuberosin exerts antihypertensive effects by inhibiting the L-type CaV1.2 channel. Demethylsuberosin has antioxidant and anti-inflammatory activities. Demethylsuberosin also exhibits neuroprotective activities against glutamate-induced toxicity in primary cultured rat cortical cells .
4
Quinpirole
Quinpirole
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4 Cited Publications
Cat. No.: HY-B1752
CAS No.: 80373-22-4
Synonyms: LY 171555; (-)-LY 141865
Target:  

Dopamine Receptor Calcium Channel Bcl-2 Family iGluR Apoptosis

Research Areas:  

Neurological Disease

Quinpirole (LY 171555; (-)-LY 141865) is a D2/D3 dopamine receptor agonist and a CaV1.3 calcium channel modulator. Quinpirole normalizes dendritic spine density in dopamine-depleted striatum, upregulates the protein expression of BCL2 and GluR2, downregulates the protein expression of BAX, and delays the onset of seizures. Quinpirole enhances learning and memory, inhibits neuronal apoptosis (apoptosis), and induces anxiety-like, stereotyped, and compulsive behaviors. Quinpirole disrupts prepulse inhibition in rhesus monkeys, enhances the activity of paraventricular thalamic neurons to promote recovery from Isoflurane anesthesia, and alters the composition of the gut microbiota in rats. Quinpirole can be used in research related to dyskinesia, pain, epilepsy, and neurological disorders including anxiety disorder, obsessive-compulsive disorder, and schizophrenia .
3
WL47 TFA
WL47 TFA
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3 Cited Publications
Cat. No.: HY-P2288A
Target:  

Peptides

Research Areas:  

Cancer

WL47 TFA, a high-affinity cavolin-1 (CAV1) ligand (Kd=23 nM), is a potent disrupter of CAV1 oligomers. WL47 TFA shows selectivity for CAV1 over BSA, casein and HEWL. WL47 TFA is 80% smaller in length than the original T20 (HY-P0052) parent sequence and can be used for the study of caveolin-1 function .
3
Menaquinone-7
Menaquinone-7
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3 Cited Publications
Cat. No.: HY-112499
CAS No.: 2124-57-4
Purity:  ≥98.0%
Synonyms: Vitamin K2-7; Vitamin K2(35); Vitamin MK-7
Target:  

TGF-beta/Smad

Research Areas:  

Cardiovascular Disease

Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .
3
Menaquinone-7 (Standard)
Menaquinone-7 (Standard)
0 Images
3 Cited Publications
Cat. No.: HY-112499R
CAS No.: 2124-57-4
Synonyms: Vitamin K2-7(Standard); Vitamin K2(35)(Standard); Vitamin MK-7 (Standard)
Target:  

Endogenous Metabolite Reference Standards

Research Areas:  

Cardiovascular Disease

Menaquinone-7 (Standard) is the analytical standard of Menaquinone-7. This product is intended for research and analytical applications. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .
2
L-Ascorbic acid (Standard)
L-Ascorbic acid (Standard)
0 Images
2 Cited Publications
Cat. No.: HY-B0166R
CAS No.: 50-81-7
Synonyms: L-Ascorbate (Standard); Vitamin C (Standard)
Category:  

Natural Products Microorganisms Moringa oleifera Lam. Disease markers Endocrine diseases Moringaceae Nervous System Disorder Plants Endogenous metabolite

Target:  

Reference Standards Reactive Oxygen Species (ROS) Calcium Channel Apoptosis Endogenous Metabolite

L-Ascorbic acid (Standard) is the analytical standard of L-Ascorbic acid. This product is intended for research and analytical applications. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
2
ML218
ML218
0 Images
2 Cited Publications
Cat. No.: HY-103309
CAS No.: 1346233-68-8
Purity:  99.49%
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

ML218 is a potent, selective and orally active T-type Ca 2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier .
1
TTA-A2
TTA-A2
0 Images
1 Cited Publications
Cat. No.: HY-111828
CAS No.: 953778-63-7
Purity:  99.33%
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

TTA-A2 is a potent, selective and orally active t-type voltage gated calcium channel antagonist with reduced pregnane X receptor (PXR) activation. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy .
1
ω-Agatoxin IVA
ω-Agatoxin IVA
0 Images
1 Cited Publications
Cat. No.: HY-P1080
CAS No.: 145017-83-0
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease Neurological Disease

ω-Agatoxin IVA is a potent, selective P/Q type Ca 2+ (Cav2.1) channel blocker with IC50 values of 2 nM and 90 nM. ω-Agatoxin IVA inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA inhibits Capsaicin (HY-10448)-induced CGRP release and vasodilation. ω-Agatoxin IVA can be used for the research of neurological and cardiovascular disease .
1
ω-Agatoxin IVA TFA
ω-Agatoxin IVA TFA
0 Images
1 Cited Publications
Cat. No.: HY-P1080A
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca 2+ (Cav2.1) channel blocker with IC50 values of 2 nM and 90 nM. ω-Agatoxin IVA TFA inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA inhibits Capsaicin (HY-10448)-induced CGRP release and vasodilation. ω-Agatoxin IVA TFA can be used for the research of neurological and cardiovascular disease .
1
SNX-482
SNX-482
0 Images
1 Cited Publications
Cat. No.: HY-P1074
CAS No.: 203460-30-4
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

SNX-482, a peptide, is a potent, high affinity, selective and voltage-dependent R-type CaV2.3 channel blocker with an IC50 of 30 nM. SNX-482 has antinociceptive effect .
1
Cav 2.2 blocker 1
Cav 2.2 blocker 1
0 Images
1 Cited Publications
Cat. No.: HY-119373
CAS No.: 1567335-29-8
Purity:  98.78%
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain, with an IC50 of 1 nM .
1
(2R/S)-6-PNG
(2R/S)-6-PNG
0 Images
1 Cited Publications
Cat. No.: HY-115681
CAS No.: 68682-01-9
Purity:  99.88%
Synonyms: 6-Prenylnaringenin; (±)-6-Prenylnaringenin
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

(2R/S)-6-PNG (6-Prenylnaringenin) is a potent and reversible Cav3.2 T-type Ca 2+ channels (T-channels) blocker. (2R/S)-6-PNG can penetrate the blood-brain barrier (BBB). (2R/S)-6-PNG suppresses neuropathic and visceral pain in mice .
5,6-Epoxyeicosatrienoic acid
5,6-Epoxyeicosatrienoic acid
0 Images
Cat. No.: HY-132184
CAS No.: 87173-80-6
Purity:  ≥99.0%
Synonyms: 5,6-EET; (±)5,6-EpETrE
Target:  

Adrenergic Receptor Calcium Channel

Research Areas:  

Endocrinology

5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50=0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2.
L-Ascorbic acid-13C6
L-Ascorbic acid-13C6
0 Images
Cat. No.: HY-B0166S
CAS No.: 1354064-87-1
Synonyms: L-Ascorbate-13C6; Vitamin C-13C6
L-Ascorbic acid- 13C6 is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
CaV1.3 antagonist-1
CaV1.3 antagonist-1
0 Images
Cat. No.: HY-134542
CAS No.: 1391385-57-1
Purity:  98.38%
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research .
SAK3
SAK3
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Cat. No.: HY-120597
CAS No.: 1256269-87-0
Purity:  99.80%
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

SAK3 is a potent T-type voltage-gated Ca 2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca 2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice . SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity .
Actein
Actein
0 Images
Cat. No.: HY-N6872
CAS No.: 18642-44-9
Category:  

Triterpenes Terpenoids Ranunculaceae Plants  Cimicifuga foetida Linn. Disease Research Fields Cancer

Target:  

JNK Akt Apoptosis Autophagy Reactive Oxygen Species (ROS)

Actein, a triterpene glycoside, shows an inhibitory effect on cancer cells, which is isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in bladder cancer. Actein has little toxicity in vivo .
Assay Types